|
|
malonyl-[BryP_acyl-carrier_protein] + 5-hydroxy-8-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-6,6-dimethyl-3,7-dioxooctanoyl-[BryC_PKS] + holo_[BryD_polyketide_synthase] + NADPH + H+ <=> 3,5,7-trihydroxy-10-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-8,8-dimethyl-9-oxodecanoyl-[BryD_PKS] + holo_[BryP_acyl-carrier_protein] + holo_[BryC_polyketide_synthase] + CO2 + NADP+
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20476
|
|
|
|
malonyl-CoA + holo_[BryP_acyl-carrier_protein] <=> CoA + malonyl-[BryP_acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
| |
MetaCyc:
RXN-20482
|
|
|
|
malonyl-CoA + holo_[BryU_acyl-carrier_protein] <=> CoA + malonyl-[BryU_acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
| |
MetaCyc:
RXN-20481
|
|
|
|
malonyl-[BryP_acyl-carrier_protein] + D-lactyl-[BryA_polyketide_synthase] + NADPH + H+ <=> (5R,7R,8R)-5,7,8-trihydroxy-3-oxononanoyl-[BryA_polyketide_synthase] + CO2 + holo_[BryP_acyl-carrier_protein] + NADP+
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20463
|
|
|
|
holo_[BryA_polyketide_synthase] + 3-phospho-D-glycerate + NADPH + H+ <=> D-lactyl-[BryA_polyketide_synthase] + phosphate + H2O + NADP+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-20460
|
|
|
|
malonyl-[BryP_acyl-carrier_protein] + (2E,5Z,7S,8E,13E,15S,17R,18R)-7,15,17,18-tetrahydroxy-5,13-bis(2-methoxy-2-oxoethylidene)-10,10-dimethyl-11-oxononadeca-2,8-dienoyl-[BryC_PKS] + S-adenosyl-L-methionine <=> 4-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-2,2-dimethyl-3-oxobutanoyl-[BryC_PKS] + CO2 + holo_[BryP_acyl-carrier_protein] + S-adenosyl-L-homocysteine + H+
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20474
|
|
|
|
malonyl-[BryU_acyl-carrier_protein] + H+ <=> acetyl-[BryU_acyl-carrier_protein] + CO2
|
4.1.1.M15
|
–
|
| |
MetaCyc:
RXN-20480
|
|
|
|
3-methylacetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA_polyketide_synthase] <=> (3E,5S,7R,8R)-5,7,8-trihydroxy-3-(2-methoxy-2-oxoethylidene)nonanoyl-[BryA_polyketide_synthase]
|
5.3.3
|
–
|
| |
MetaCyc:
RXN-20467
|
|
|
|
3-acetyl-(3,5R,7R,8R)-3,5,7,8-tetrahydroxynonanoyl-[BryA_polyketide_synthase] <=> 3-acetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA_polyketide_synthase] + H2O
|
4.2.1.M29
|
–
|
| |
MetaCyc:
RXN-20465
|
|
|
|
malonyl-[BryP_acyl-carrier_protein] + (3E,5S,7R,8R)-5,7,8-trihydroxy-3-(2-methoxy-2-oxoethylidene)nonanoyl-[BryA_polyketide_synthase] + holo_[BryB_polyketide_synthase] + S-adenosyl-L-methionine + NADPH + H+ <=> (5S,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-3,9-dioxoheptadec-6-enoyl-[BryB_polyketide_synthase] + holo_[BryP_acyl-carrier_protein] + holo_[BryA_polyketide_synthase] + S-adenosyl-L-homocysteine + CO2 + NADP+ + H2O
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20468
|
|
|
|
(6E,11E,13S,15R,16R)-3-acetyl-3,5,13,15,16-pentahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-6-enoyl-[BryB_polyketide_synthase] <=> (6E,11E,13S,15R,16R)-3-acetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase] + H2O
|
4.2.1.M29
|
–
|
| |
MetaCyc:
RXN-20470
|
|
|
|
acetyl-[BryU_acyl-carrier_protein] + (5S,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-3,9-dioxoheptadec-6-enoyl-[BryB_polyketide_synthase] + H2O <=> (6E,11E,13S,15R,16R)-3-acetyl-3,5,13,15,16-pentahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-6-enoyl-[BryB_polyketide_synthase] + holo_[BryU_acyl-carrier_protein] + H+
|
2.3.3.M3
|
–
|
| |
MetaCyc:
RXN-20469
|
|
|
|
malonyl-[BryP_acyl-carrier_protein] + 4-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-2,2-dimethyl-3-oxobutanoyl-[BryC_PKS] + NADPH + H+ <=> 5-hydroxy-8-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-6,6-dimethyl-3,7-dioxooctanoyl-[BryC_PKS] + CO2 + holo_[BryP_acyl-carrier_protein] + NADP+
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20475
|
|
|
|
acetyl-[BryU_acyl-carrier_protein] + (5R,7R,8R)-5,7,8-trihydroxy-3-oxononanoyl-[BryA_polyketide_synthase] + H2O <=> 3-acetyl-(3,5R,7R,8R)-3,5,7,8-tetrahydroxynonanoyl-[BryA_polyketide_synthase] + holo_[BryU_acyl-carrier_protein] + H+
|
2.3.3.M3
|
–
|
| |
MetaCyc:
RXN-20464
|
|
|
|
(6E,11E,13S,15R,16R)-3-methylacetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase] <=> (3E,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-3,11-di(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase]
|
5.3.3
|
–
|
| |
MetaCyc:
RXN-20472
|
|
|
|
S-adenosyl-L-methionine + (6E,11E,13S,15R,16R)-3-acetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase] <=> S-adenosyl-L-homocysteine + (6E,11E,13S,15R,16R)-3-methylacetyl-5,13,15,16-tetrahydroxy-11-(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase]
|
2.1.1
|
–
|
| |
MetaCyc:
RXN-20471
|
|
|
|
S-adenosyl-L-methionine + 3-acetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA_polyketide_synthase] <=> S-adenosyl-L-homocysteine + 3-methylacetyl-(5R,7R,8R)-5,7,8-trihydroxynon-2-enoyl-[BryA_polyketide_synthase]
|
2.1.1
|
–
|
| |
MetaCyc:
RXN-20466
|
|
|
|
malonyl-[BryP_acyl-carrier_protein] + (3E,6E,11E,13S,15R,16R)-5,13,15,16-tetrahydroxy-3,11-di(2-methoxy-2-oxoethylidene)-8,8-dimethyl-9-oxoheptadec-2,6-dienoyl-[BryB_polyketide_synthase] + holo_[BryC_polyketide_synthase] + NADPH + H+ <=> (2E,5Z,7S,8E,13E,15S,17R,18R)-7,15,17,18-tetrahydroxy-5,13-bis(2-methoxy-2-oxoethylidene)-10,10-dimethyl-11-oxononadeca-2,8-dienoyl-[BryC_PKS] + holo_[BryP_acyl-carrier_protein] + CO2 + holo_[BryB_polyketide_synthase] + H2O + NADP+
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-20473
|
|
|
|
3,5,7-trihydroxy-10-[(4Z)-4-(2-methoxy-2-oxoethylidene)-6-[(1E,6E)-8-methoxy-3,3-dimethyl-4,8-dioxo-6-[(2S,4R,5R)-2,4,5-trihydroxyhexyl]octa-1,6-dien-1-yl]oxan-2-yl]-8,8-dimethyl-9-oxodecanoyl-[BryD_PKS] <=> bryostatin_0 + holo_[BryD_polyketide_synthase]
|
not assigned
|
–
|
| |
MetaCyc:
RXN-20477
|
|
